gene

LINGO2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about LINGO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

LINGO2 Gene

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🧬 Gene Info

Gene Symbol	LINGO2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Ensembl ID	ENSG00000145388
GeneCards	LINGO2
Human Protein Atlas	LINGO2
Homodimer Formation	LINGO2 can form homodimers with itself
Heterodimer Formation	Interacts with LINGO1, LINGO3, and LINGO4
Complex Formation	Associates with NgR1 (Nogo-66 receptor), p75NTR, and Troy
Dopaminergic Neuron Survival	LINGO2 affects survival of substantia nigra neurons
Myelin Integrity	Altered oligodendrocyte function
Neuroinflammation	Modulation of microglial responses
α-Synuclein Aggregation	Potential interaction with aggregation pathways
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LINGO2 Gene

gene · 1593 words

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Pathway Diagram

graph TD
    LINGO2["LINGO2"]
    neurodegeneration["neurodegeneration"]
    LINGO2 -->|"implicated_in"| neurodegeneration
    style LINGO2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning LINGO2 in their description or question text

No additional research found