gene

LRP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1509Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional receptor involved in endocytosis, cell signaling, and Aβ clearance across the blood-brain barrier. Implicated in Alzheimer disease pathogenesis through regulation of amyloid-beta transport and tau uptake.

View on Wiki →

🧬 Gene Info

Gene Symbol	LRP1
Aliases	Low-density lipoprotein receptor-related protein 1, CD91
Protein Type	Receptor
Target Class	Receptor
Function	In the healthy nervous system, LRP1 functions as
Mechanism of Action	Modulation of receptor-mediated endocytosis and clearance pathways
Druggability	Low (0.39)
Clinical Stage	Phase III
Molecular Weight	600 kDa
Amino Acids	525 aa
Pathways	Aβ clearance, APOE trafficking, Endocytosis, MAPK, PI3K
UniProt ID	Q07954
GeneCards	LRP1
Human Protein Atlas	LRP1
Lipoprotein receptors	Binds LDL, VLDL, and apolipoprotein E (ApoE)-containing lipoproteins
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	MELATONIN
Interactions	TFR1, CAV1, ABCB1, MTNR1A, MTNR1B, APOE
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	LRP1-Dependent Tau Uptake Disruption
KG Connections	1509 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: LRP1 — PDB 2FCW Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRP1["LRP1 Receptor"] -->|"Binds"| Ligands["APOE, Abeta, tPA"]
    LRP1 -->|"Mediates"| Endocytosis["Receptor-Mediated Endocytosis"]
    Endocytosis -->|"Internalizes"| Abeta["Abeta Peptides"]
    Abeta -->|"Degraded in"| Lysosome["Lysosomes"]
    LRP1 -->|"Expressed on"| BBB["Brain Endothelium"]
    BBB -->|"Efflux of"| Clearance["Abeta Clearance to Blood"]
    LRP1 -.Downregulation.-> Accumulation["Abeta Accumulation"]
    Accumulation -.Contributes to.-> AD["Alzheimer's Disease"]

Outgoing (971)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-6784494f1741	provides_data_for	dataset	1.00
Amyloid-beta	regulates	compound	0.95
Notch Pathway	mediates	pathway	0.95
Notch Pathway Activation	mediates	pathway	0.95
AMYLOID-Β	regulates	entity	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
M2-like Macrophage Polarization	upregulates	process	0.90
Notch Signaling Activation	activates	process	0.90
DELTA LIGANDS	regulates	protein	0.90
neuronal ferroptosis	inhibits	process	0.90
Amyloid-Beta Metabolism	regulates	process	0.90
Delta ligands	mediates_ubiquitination	protein	0.90
Endothelial Cells	expressed_in	cell_type	0.90
Alzheimer's Disease	involved_in	disease	0.90
Epithelial-Mesenchymal Transition	associated_with	process	0.90
Astrocytes	expressed_in	cell_type	0.90
Amyloid-Β Peptides	regulates	molecule	0.90
Microglial Phagocytosis of Amyloid-β	involved_in	process	0.85
DLL4	upregulates	gene	0.85
Anti-PD-1 Resistance	causes	phenotype	0.85
DELTA LIGANDS	mediates	protein	0.85
Ubiquitination	mediates	process	0.85
Brain Homeostasis	associated_with	process	0.85
Late-Onset Alzheimer'S Disease	associated_with	disease	0.85
endothelial dysfunction	contributes_to	phenotype	0.85
amyloid-beta metabolism	modulates	process	0.85
blood-brain barrier integrity	biomarker_for	phenotype	0.85
Alzheimer	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
BRAIN HOMEOSTASIS	associated_with	entity	0.85
LIPID METABOLISM	regulates	entity	0.85
NEURODEGENERATION	associated_with	gene	0.82
Blood-Brain Barrier Function	regulates	process	0.80
mitochondria transfer	promotes	process	0.80
Aβ production	inhibits	process	0.80
iron accumulation	decreases	process	0.80
GPX4 expression	increases	gene	0.80
MDK	interacts_with	protein	0.80
DLL4	regulates	protein	0.80
NOTCH2	regulates	gene	0.80
β-catenin	regulates	protein	0.80
NF-κB signaling	activates	pathway	0.80
DLL4-NOTCH2-CCL2 axis	modulates	pathway	0.80
Pulmonary Arterial Hypertension	implicated_in	disease	0.80
Pulmonary Arterial Hypertension	associated_with	disease	0.80
Brain Homeostasis	maintains	process	0.80
apoE	regulates	gene	0.80
Alzheimer's Disease	associated_with	disease	0.80
Leukemia	targets	disease	0.80

Incoming (538)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-6784494f1741	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
APOE	associated_with	gene	0.90
EPSIN1	regulates	gene	0.90
EPSIN2	regulates	gene	0.90
APOE	co_mentioned_with	gene	0.90
AMYLOID	associated_with	gene	0.90
endothelial cells	expressed_in	cell_type	0.90
astrocytes	expressed_in	cell_type	0.90
h-84808267	targets_gene	hypothesis	0.90
h-7e0b5ade	targets_gene	hypothesis	0.90
h-b948c32c	targets_gene	hypothesis	0.90
h-4dd0d19b	targets_gene	hypothesis	0.90
APOPTOSIS	associated_with	gene	0.82
h-84808267	targets	hypothesis	0.80
h-7e0b5ade	targets	hypothesis	0.80
h-b948c32c	targets	hypothesis	0.80
h-4dd0d19b	targets	hypothesis	0.80
UBIQUITIN	regulates	entity	0.75
APP	associated_with	gene	0.74
YBX1	activates	protein	0.72
YBX1	regulates	protein	0.72
APOE	protects_against	gene	0.70
TAU	causes	protein	0.70
TAU	biomarker_for	protein	0.70
ENDOTHELIAL CELLS	regulates	cell_type	0.70
MELATONIN	activates	drug	0.70
CREB	interacts_with	gene	0.70
SYNAPTIC PLASTICITY	protects_against	phenotype	0.70
CLU	associated_with	gene	0.66
AKT	associated_with	gene	0.65
AQP4	associated_with	gene	0.65
GPX4	inhibits	gene	0.65
AKT	activates	gene	0.65
BAX	activates	gene	0.65
BCL2	activates	gene	0.65
BDNF	activates	gene	0.65
AKT	interacts_with	gene	0.65
AKT	promotes	gene	0.65
AKT	inhibits	gene	0.65
AKT	phosphorylates	gene	0.65
BAX	phosphorylates	gene	0.65
BCL2	phosphorylates	gene	0.65
BDNF	phosphorylates	gene	0.65
APP	regulates	gene	0.65
PICALM	interacts_with	gene	0.65
CANCER	sensitizes_to	disease	0.65
DEPRESSION	processes	disease	0.65
DEPRESSION	regulates	disease	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian-Synchronized LRP1 Pathway Activation	0.526	neurodegeneration	Blood-brain barrier transport mechanisms
LRP1-Dependent Tau Uptake Disruption	0.437	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271]	Mushtaq T, Hameed H, Khan MA, Tariq U, H	Molecular neurobiology	2026	0
Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microg [PMID:41621577]	Guo H, Peng X, Zhang X, Ruganzu JB, Wu X	Experimental cell research	2026	0
Osteoclast-secreted galectin-3 promotes articular cartilage degeneration in OVX [PMID:40609733]	Chen L, Hong H, Yang Z, Zhong Y, Sun S e	Osteoarthritis Cartilage	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cogn [PMID:41933339]	Huang N, Hong R, Cui X, Cao L, Shi L et	J Nanobiotechnology	2026	0
Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR [PMID:41934727]	Li D, Zhang Y, Wang R, Jin L, Cui X et a	Neurotherapeutics	2026	0
Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296]	Gong W, Hui W, Qiao S, Ji Q, Liu M et al	Adv Sci (Weinh)	2026	0
Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs. [PMID:41785850]	Teng F, Liu J, Cui T, Tan X, Liu K, Hou	Cell	2026	0
Lysosomal trafficking markers covering PSAP, PGRN, SORT1 and LRP1 in body liquid [PMID:41579784]	Poniatowski ŁA, Siwińska A, Acewicz A, K	Forensic science international	2026	0
Mitochondrial calcium uniporter knockdown in hippocampal neurons effectively att [PMID:41687804]	Wu L, Hou F, Wang Z, Wu M, Wang X, Cao J	Experimental neurology	2026	0
ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818]	["Li X", "Huang J", "Zhou Y", "Chen X",	International journal of pharm	2026	0
Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS m [PMID:40595262]	Sagulkoo P, Chuntakaruk H, Suratanee A,	Scientific reports	2025	0
Inhibition of tau neuronal internalization using anti-tau single domain antibodi [PMID:40175345]	["Danis C", "Dupr\u00e9 E", "Bouillet T"	Nature communications	2025	0
Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial [PMID:41430102]	Gong Z, Zhang M, Liu N, Asam K, Martellu	The journal of headache and pa	2025	0
Ganglioside sialylation modulates tau internalization and pathology spread. [PMID:41398374]	Li S, Chen Y, Song T, Liu D, Wu R, Yang	Molecular psychiatry	2025	0
Microglia internalize tau monomers and fibrils using distinct receptors but simi [PMID:39713861]	Falkon KF, Danford L, Gutierrez Kuri E,	Alzheimer's & dementia : the j	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain isc [PMID:38906140]	Zhou J, Zhang L, Peng J, Zhang X, Zhang	Cell metabolism	2024	0

LRP1

Understanding Entity Pages

Summary

Wiki Pages (21)

LRP1 Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Pathway Diagram

Outgoing (971)

Incoming (538)

Targeting Hypotheses (2)

Mentioning Analyses (5)

Tau propagation mechanisms and therapeutic interception points

Senescent cell clearance as neurodegeneration therapy

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

4R-tau strain-specific spreading patterns in PSP vs CBD

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (20)

LRP1

Understanding Entity Pages

Summary

Wiki Pages (21)

LRP1 Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Astrocyte Reactivity Mechanism

CBS/PSP Clinical Trials Guide

Blood-Brain Barrier Dysfunction in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

psp-tauopathy

Infectious Triggers in Alzheimer's Disease

Epigenetic Alterations in Alzheimer's Disease

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease

PMN310 Anti-Amyloid for AD (NCT06750432)

Amyloid Cascade Pathway

Glia-Neuron Crosstalk in Alzheimer's Disease

vitamin-d-therapy-neurodegeneration

Pathway Diagram

Outgoing (971)

Incoming (538)

Targeting Hypotheses (2)

Mentioning Analyses (5)

Tau propagation mechanisms and therapeutic interception points

Senescent cell clearance as neurodegeneration therapy

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

4R-tau strain-specific spreading patterns in PSP vs CBD

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (20)