Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRRK2 G2019S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.95 |
| Parkinson disease | risk_factor_for | disease | 0.90 |
| RAB10 hyperphosphorylation | causes | mechanism | 0.90 |
| age-dependent motor deficits | causes | phenotype | 0.70 |
| dopaminergic dysfunction | causes | phenotype | 0.70 |
| endosomal trafficking defects | causes | mechanism | 0.70 |
| lysosomal stress response | amplifies | process | 0.70 |
| lysosomal pH elevation | causes | phenotype | 0.70 |
| neurite degeneration | causes | phenotype | 0.70 |
| RAB10 phosphorylation | enhances | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LRRK2 G2019S Kinase Inhibition for Parkinson's Disease | 0.795 | neurodegeneration | Test |
| LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from | 0.640 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 0 hypotheses
neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630
neurodegeneration | 2026-04-23 | 7 hypotheses Top: 0.780
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.89 · 2026-04-27
closed · Rounds: 4 · Score: 0.80 · 2026-04-26
closed · Rounds: 4 · Score: 0.60 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
Hypotheses and analyses mentioning LRRK2 G2019S in their description or question text
No additional research found