Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRSAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LRSAM1 |
| Full Name | Leucine Rich Repeat And Sterile Alpha Motif 1 |
| Chromosome | 9q33.3 |
| Protein Type | Ligase |
| Function | encodes an E3 ubiquitin ligase that plays a critical role in protein quality control and cellular homeostasis[@guernsey2011]. |
| Molecular Weight | 70 kDa |
| Amino Acids | 635 aa |
| Exons | 22 |
| UniProt ID | [Q6UWP7](https://www.uniprot.org/uniprot/Q6UWP7) |
| Ensembl ID | ENSG00000148450 |
| OMIM | 610933 |
| GeneCards | LRSAM1 |
| Human Protein Atlas | LRSAM1 |
| Peripheral nervous system | Dorsal root ganglia, sciatic nerve, and peripheral nerves |
| Motor [neurons](/entities/neurons) | Spinal cord motor neurons and cortical motor areas |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["LRSAM1"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LRSAM1 in their description or question text
No additional research found