Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lipid Nanoparticle: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| IL10 | transports | gene | 0.90 |
| M2 Microglia | targets | cell_type | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles | 0.529 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685] | Litvinchuk A, Suh JH, Guo JL, Lin K, Dav | Neuron | 2024 | 1 |
| The cell biology of APOE in the brain. [PMID:37805344] | Windham IA, Cohen S | Trends Cell Biol | 2024 | 1 |
| APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. [PMID:33658354] | Sienski G, Narayan P, Bonner JM, Kory N, | Sci Transl Med | 2021 | 1 |
| APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] | Serrano-Pozo A, Das S, Hyman BT | Lancet Neurol | 2021 | 1 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized [PMID:40747850] | Saadmaan G, Dalmasso MC, Maria M, Lehtis | Brain | 2026 | 0 |
| Myricanol modulates PPARγ/ACSL1/SCD1 metabolic signaling pathway to promote mito [PMID:41520958] | Zhang X, Xiang S, Tang S, Luo X, Fan L e | J Ethnopharmacol | 2026 | 0 |
| Postoperative cognitive dysfunction and neurodegeneration: From inflammation to [PMID:41679672] | Lin X, Luo Y, Zhu Q | Brain Res Bull | 2026 | 0 |
| Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246] | Strickland MR, Wang Z, Golden LR, Wang H | J Lipid Res | 2026 | 0 |
| CRISPR-Cas9 and next-generation gene editing strategies for therapeutic interven [PMID:41931258] | Khan MS, Zafar I, Jamal A, Bahwerth FS, | Acta Neurol Belg | 2026 | 0 |
| Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer' [PMID:41933197] | Tabuena DR, Jang SS, Grone B, Yip O, Aer | Nat Aging | 2026 | 0 |
| Apolipoprotein E proteotyping as a valid alternative to genotyping in clinical p [PMID:41940854] | Alcalá Ramírez Del Puerto JM, Ortega-Mad | J Alzheimers Dis | 2026 | 0 |
| Associations between air pollution and markers of neuroinflammation, synaptic dy [PMID:41944915] | Kimura K, Driscoll I, Cook N, Shahzad S, | Neurotoxicity research | 2026 | 0 |
| Alteration in oral and non-oral tissues in ligature-induced periodontitis mice w [PMID:41947612] | Kim AR, Yoo YJ, Bak EJ | Eur J Oral Sci | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms [PMID:40835432] | ["Chen Jiajie", "Zhao Shuoyan", "Zhou Yi | Bioscience trends | 2026 | 0 |
| Genetic modifiers of APOE-ε4-associated cognitive decline. [PMID:41720779] | Contreras AG, Walters S, Eissman JM, Arc | Nature communications | 2026 | 0 |
| Protective ApoE variants support neuronal function by effluxing oxidized phospho [PMID:41338186] | Ralhan I, Do AD, Bae JY, Feringa FM, Cai | Neuron | 2026 | 0 |
| Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268] | ["Srivastav Jyotsna", "Sharma Sachin"] | Frontiers in medicine | 2025 | 0 |
| Cell type-specific roles of APOE4 in Alzheimer disease. [PMID:38191720] | ["Blumenfeld Jessica", "Yip Oscar", "Kim | Nature reviews. Neuroscience | 2024 | 0 |