Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAN2B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MAN2B1 |
| Full Name | Mannosidase Alpha Class 2B Member 1 |
| Chromosome | 19q13.13 |
| Function | The MAN2B1 gene encodes acid alpha-mannosidase, a lysosomal hydrolase that catalyzes the hydrolysis of terminal alpha-mannose residues from mannose-containing oligosaccharides. |
| Primary Expression | most tissues, with highest levels in: |
| Molecular Weight | 280 kDa |
| UniProt ID | O00754 |
| NCBI Gene ID | 4125 |
| Ensembl ID | ENSG00000112837 |
| OMIM | 604458 |
| GeneCards | MAN2B1 |
| Human Protein Atlas | MAN2B1 |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MAN2B1["MAN2B1"]
TREM2["TREM2"]
MAN2B1 -->|"associated with"| TREM2
oxidized_phosphatidylcholines["oxidized phosphatidylcholines"]
MAN2B1 -->|"associated with"| oxidized_phosphatidylcholines
neurodegeneration["neurodegeneration"]
MAN2B1 -->|"implicated in"| neurodegeneration
style MAN2B1 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| TREM2 | associated_with | gene | 0.80 |
| oxidized phosphatidylcholines | associated_with | chemical | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||