Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAPK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Mitogen-Activated Protein Kinase 4 (ERK4) - atypical MAPK family member involved in neuronal signaling, stress responses, and neurodegenerative disease pathogenesis
| Gene Symbol | MAPK4 |
| Full Name | Mitogen-Activated Protein Kinase 4 |
| Aliases | Mitogen-Activated Protein Kinase 4 (ERK4) |
| Chromosome | 18q12.2 |
| Primary Expression | Brain (neurons, astrocytes), various tissues |
| Molecular Weight | ~65 kDa |
| Amino Acids | 632 aa |
| Exons | 16 coding exons |
| Pathways | MAPK |
| UniProt ID | P31196 |
| NCBI Gene ID | 5595 |
| Ensembl ID | ENSG00000116539 |
| OMIM | 617957 |
| GeneCards | MAPK4 |
| Human Protein Atlas | MAPK4 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MAPK4["MAPK4"]
neurodegeneration["neurodegeneration"]
MAPK4 -->|"implicated_in"| neurodegeneration
style MAPK4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||