gene

MARCHF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MARCHF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive page on MARCHF2, an E3 ubiquitin ligase involved in membrane trafficking, immune regulation, and neurodegenerative disease pathways.

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🧬 Gene Info

Gene Symbol	MARCHF2
Aliases	MARCH2
Chromosome	1p36.21
Protein Type	Ligase
Function	is an E3 ubiquitin ligase belonging to the MARCH family of membrane-associated RING-CH proteins.
Primary Expression	Ubiquitous, high in brain, heart, lung
Subcellular Localization	Endosomes, plasma membrane, Golgi apparatus
Molecular Weight	26 kDa
Amino Acids	229 aa
Exons	3
UniProt ID	Q9P2R3
GeneCards	MARCHF2
Human Protein Atlas	MARCHF2
Brain	Neuronal and glial cells express MARCHF2, with particular abundance in regions vulnerable to neurodegeneration.
Immune System	High expression in lymphoid tissues, including spleen, thymus, and peripheral blood leukocytes.
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MARCHF2 — AlphaFold Q9P2R3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MARCHF2 — Membrane-Associated RING-CH Finger 2

gene · 1964 words

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MARCHF2 Protein

protein · 1533 words

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Pathway Diagram

graph TD
    MARCHF2["MARCHF2"]
    neurodegeneration["neurodegeneration"]
    MARCHF2 -->|"implicated_in"| neurodegeneration
    style MARCHF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MARCHF2 in their description or question text

No additional research found