MBD3

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolMBD3
Namemethyl-CpG binding domain protein 3
Typeprotein-coding
Sourcemygene

Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediat

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