protein

MBL2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MBL2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	MBL2PROTEIN
Function	is a key component of the innate immune system and a member of the collectin family of proteins.
Subcellular Localization	</b></td><td>Plasma, secreted</td></tr>
Molecular Weight	26 kDa
GeneCards	MBL2PROTEIN
Human Protein Atlas	MBL2PROTEIN
Collagen-like regions	Triple helical domains that mediate trimerization
C-type lectin domains	Carbohydrate recognition domains (CRDs) that bind to mannose, N-acetylglucosamine, and fucose residues on pathogen surfaces
Neck regions	Alpha-helical segments that facilitate oligomerization
N-terminal cysteine-rich regions	Involved in disulfide bond formation
Peripheral immune activation	Circulating MBL2 can activate the complement system, leading to systemic inflammation that propagates to the central nervous system
Blood-brain barrier (BBB) modulation	MBL2 and complement activation products can compromise BBB integrity, allowing peripheral immune cells to enter the brain
Microglial activation	The complement pathway contributes to neuroinflammation in PD
Amyloid-β clearance	Some studies suggest MBL2 may aid in clearing amyloid-beta plaques through complement-mediated phagocytosis
Synaptic pruning	Excessive complement activation driven by MBL2 may contribute to synaptic loss in AD
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Mannose-Binding Lectin 2 Protein

protein · 702 words

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Pathway Diagram

graph TD
    MBL2PROTEIN["MBL2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    MBL2PROTEIN -->|"implicated_in"| neurodegeneration
    style MBL2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found