gene

MEF2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEF2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive gene page for MEF2B (Myocyte Enhancer Factor 2B), a transcription factor involved in neuronal development, synaptic plasticity, and neurodegenerative disease mechanisms

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🧬 Gene Info

Gene Symbol	MEF2B
Full Name	MEF2B (Myocyte Enhancer Factor 2B)
Aliases	Myocyte Enhancer Factor 2B
Chromosome	19p13.11
Protein Type	Gene
Function	encodes a transcription factor belonging to the MADS (MEF2, Agamous, Deficiens, serum response factor) box family of DNA-binding proteins.
Primary Expression	multiple tissues including adrenal, heart, intestine, kidney, lung, and stomach, reflecting its role in developmental transcriptional programs
Amino Acids	365 aa
GeneCards	MEF2B
Human Protein Atlas	MEF2B
Dimerization	MEF2 proteins form homodimers and heterodimers with other MEF2 family members, expanding their combinatorial diversity
DNA binding	The MADS domain directly contacts the major groove of DNA at MEF2 response elements
Cofactor recruitment	The domain interacts with various transcriptional coactivators and corepressors, including HDACs
Highest expression	Lymphoid tissues including lymph node (RPKM 18.6) and appendix (RPKM 7.2)
Moderate expression	Adrenal gland, small intestine, lung, stomach, kidney, and heart
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MEF2B (Myocyte Enhancer Factor 2B)

gene · 2829 words

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Pathway Diagram

graph TD
    MEF2B["MEF2B"]
    neurodegeneration["neurodegeneration"]
    MEF2B -->|"implicated_in"| neurodegeneration
    style MEF2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MEF2B in their description or question text

No additional research found