protein

MEKK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEKK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MEKK1 (MAP3K1) is a serine/threonine kinase that activates both the MAPK and JNK pathways, playing complex roles in stress response, cell survival, and neurodegeneration.

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🔬 Protein Info

Gene Symbol	MEKK1
Aliases	MAP3K1
Chromosome	5q11.2
Protein Family	MAP3K serine/threonine kinases
Protein Type	Kinase
Function	This activation leads to phosphorylation of JNK isoforms, which then phosphorylate transcription factors including c-Jun, driving expression of genes involved in stress response, cell cycle regulation
Molecular Weight	164.3 kDa
Amino Acids	413 aa
Pathways	MAPK, MAPK Pathway
UniProt ID	[Q13233](https://www.uniprot.org/uniprot/Q13233)
GeneCards	MEKK1
Human Protein Atlas	MEKK1
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MEKK1 Protein

protein · 1398 words

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Pathway Diagram

graph TD
    MEKK1["MEKK1"]
    neurodegeneration["neurodegeneration"]
    MEKK1 -->|"implicated_in"| neurodegeneration
    style MEKK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MEKK1 in their description or question text

No additional research found