protein

MGLUR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MGLUR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Metabotropic glutamate receptor 3 (mGluR3/GRM3) is a Group II GPCR predominantly expressed on glial cells, modulating glutamate transport, neuroinflammation, and synaptic plasticity in neurodegenerative diseases.

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🔬 Protein Info

Gene Symbol	MGLUR3
Aliases	mGluR3/GRM3
Chromosome	7q21.1
Protein Type	Receptor
Function	mGluR3 is a Group II metabotropic glutamate receptor that modulates glutamatergic and GABAergic transmission.
Primary Expression	the brain and implicated in cognitive function
Molecular Weight	98 kDa
Exons	11
GeneCards	MGLUR3
Human Protein Atlas	MGLUR3
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR3 Protein

protein · 746 words

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Pathway Diagram

graph TD
    MGLUR3["MGLUR3"]
    neurodegeneration["neurodegeneration"]
    MGLUR3 -->|"implicated_in"| neurodegeneration
    style MGLUR3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MGLUR3 in their description or question text

No additional research found