cell_type
MICROGLIA
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about MICROGLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
10795Connections
0Hypotheses
2Analyses
50Outgoing
50Incoming
0Experiments
2Debates
Summary
Resident immune cells of the central nervous system. Microglia survey the brain parenchyma, clear debris, prune synapses, and respond to injury. In neurodegenerative diseases, chronic microglial activation drives neuroinflammation through complement cascade and cytokine release.
AI-generated illustration
Regenerate portrait ↻Wiki Pages (1)
Knowledge base pages for this entity
Pathway Diagram
graph TD
subgraph Therapeutic["Therapeutic"]
MICROGLIA["MICROGLIA"] -->|"expressed in"| TREM2["TREM2"]
TREM2_3["TREM2"] -->|"expressed in"| MICROGLIA["MICROGLIA"]
end
subgraph Pathology["Pathology"]
MICROGLIA["MICROGLIA"] -->|"associated with"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
MICROGLIA["MICROGLIA"] -->|"associated with"| NEURON["NEURON"]
MICROGLIA["MICROGLIA"] -->|"associated with"| TNF["TNF"]
MICROGLIA["MICROGLIA"] -->|"associated with"| SNCA["SNCA"]
MICROGLIA["MICROGLIA"] -->|"associated with"| TAU["TAU"]
MICROGLIA["MICROGLIA"] -->|"associated with"| TREM2_1["TREM2"]
MICROGLIA["MICROGLIA"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
AMYLOID["AMYLOID"] -->|"associated with"| MICROGLIA["MICROGLIA"]
APOE["APOE"] -->|"associated with"| MICROGLIA["MICROGLIA"]
end
subgraph Signaling["Signaling"]
MICROGLIA["MICROGLIA"] -->|"activates"| TREM2_2["TREM2"]
INFLAMMATION["INFLAMMATION"] -->|"activates"| MICROGLIA["MICROGLIA"]
C1Q["C1Q"] -->|"activates"| MICROGLIA["MICROGLIA"]
TREM2_4["TREM2"] -->|"regulates"| MICROGLIA["MICROGLIA"]
end
style MICROGLIA fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style TREM2 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style SNCA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TAU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style C1Q fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2_4 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AMYLOID fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0Outgoing (4851)
| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | implicated_in | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| Autoimmune | activates | disease | 1.00 |
| Multiple Sclerosis | activates | disease | 1.00 |
| Tauopathy | activates | disease | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| DEMENTIA | associated_with | disease | 1.00 |
| C1Q | associated_with | gene | 1.00 |
| STROKE | associated_with | disease | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| Aging | activates | disease | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| Alzheimer | contributes_to | disease | 1.00 |
| DEPRESSION | associated_with | gene | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Neurodegeneration | contributes_to | disease | 1.00 |
| C3 | associated_with | gene | 1.00 |
| Als | contributes_to | disease | 1.00 |
| HIPPOCAMPUS | activates | brain_region | 1.00 |
| Stem Cell | activates | pathway | 1.00 |
| Als | implicated_in | disease | 1.00 |
| MULTIPLE SCLEROSIS | associated_with | disease | 1.00 |
| Parkinson | implicated_in | disease | 1.00 |
| Neuroinflammation | contributes_to | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| NEURON | activates | gene | 1.00 |
| Alzheimer | expressed_in | disease | 1.00 |
| Inflammation | contributes_to | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Alzheimer | inhibits | disease | 1.00 |
| Dementia | therapeutic_target | disease | 1.00 |
| Neuroinflammation | implicated_in | disease | 1.00 |
| Aging | implicated_in | disease | 1.00 |
| Inflammation | interacts_with | disease | 1.00 |
| Neuroinflammation | interacts_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | activates | disease | 1.00 |
| GFAP | associated_with | protein | 1.00 |
| ISCHEMIA | associated_with | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| TRAUMATIC BRAIN INJURY | associated_with | disease | 1.00 |
| C3 | activates | gene | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| SUBSTANTIA NIGRA | associated_with | brain_region | 1.00 |
| Parkinson | causes | disease | 1.00 |
| HIPPOCAMPUS | associated_with | brain_region | 1.00 |
| Ischemia | regulates | disease | 1.00 |
| SYNUCLEIN | associated_with | protein | 1.00 |
Incoming (5944)
| Source | Relation | Type | Str |
|---|---|---|---|
| GENES | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| TREM2 | regulates | protein | 1.00 |
| ALS | associated_with | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AMYLOID | inhibits | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| ASTROCYTES | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | implicated_in | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| NEUROINFLAMMATION | contributes_to | gene | 1.00 |
| TLR4 | activates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 1.00 |
| C1Q | activates | protein | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| ALZHEIMER | expressed_in | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| TREM2 | expressed_in | gene | 1.00 |
| DEMENTIA | activates | disease | 1.00 |
| ALZHEIMER'S DISEASE | causes | gene | 1.00 |
| ASTROCYTES | regulates | gene | 1.00 |
| ASTROCYTES | implicated_in | gene | 1.00 |
| ALZHEIMER | contributes_to | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER | implicated_in | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| MICROGLIA ACTIVATION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | contributes_to | gene | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| COMPLEMENT | activates | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| STROKE | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 1.00 |
| STROKE | activates | gene | 1.00 |
| INFLAMMATION | activates | phenotype | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| NEUROINFLAMMATION | inhibits | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
Targeting Hypotheses (0)
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Mentioning Analyses (2)
Scientific analyses that reference this entity
Which cell types show the most significant expression changes for neurodegenerat
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.682
Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)
neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.825
Experiments (0)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Related Papers (0)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Debates (2)
Multi-agent debates referencing this entity