Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MKP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MKP1 |
| Protein Family | Dual-specificity phosphatases |
| Protein Type | Phosphatase |
| Function | MKP1 is a dual-specificity phosphatase that dephosphorylates and inactivates ERK, JNK, and p38 MAP kinases. |
| Molecular Weight | 36.5 kDa |
| Pathways | MAPK signaling, MAPK |
| UniProt ID | P28562 |
| GeneCards | MKP1 |
| Human Protein Atlas | MKP1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MKP1["MKP1"]
neurodegeneration["neurodegeneration"]
MKP1 -->|"implicated_in"| neurodegeneration
style MKP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MKP1 in their description or question text
No additional research found