Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MKP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MKP3 |
| Protein Type | Phosphatase |
| Function | is a dual-specificity protein phosphatase that specifically dephosphorylates and inactivates ERK1/2 (Extracellular Signal-Regulated Kinases 1 and 2). |
| Amino Acids | 400 aa |
| GeneCards | MKP3 |
| Human Protein Atlas | MKP3 |
| D-domain (Docking motif) | The N-terminal contains a characteristic D-domain (KIM motif) that mediates specific binding to ERK1/2, ensuring substrate specificity |
| Active site pocket | The catalytic domain forms a deep pocket that accommodates the phosphorylated threonine and tyrosine residues of ERK |
| Induced fit | Substrate binding induces conformational changes that optimize catalytic efficiency |
| Pattern formation | DUSP6 regulates ERK activity gradients during embryonic development |
| Cell fate specification | Spatial control of MAPK signaling influences cell differentiation |
| Organogenesis | Critical for proper development of lung, pancreas, and other organs |
| Signal termination | Rapidly dephosphorylates ERK to limit the duration of MAPK signals |
| Cellular homeostasis | Prevents aberrant proliferation and maintains tissue architecture |
| Stress response | Modulates MAPK activation in response to growth factors and stress |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MKP3["MKP3"]
neurodegeneration["neurodegeneration"]
MKP3 -->|"implicated_in"| neurodegeneration
style MKP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning MKP3 in their description or question text
No additional research found