Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MS4A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive overview of MS4A1 (CD20), a B cell surface protein with emerging roles in neuroinflammation, Alzheimer's disease, and autoimmune disorders.
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| Gene Symbol | MS4A1 |
| Full Name | Membrane Spanning 4-Domains A1 (CD20) |
| Chromosome | 11q12.1 |
| Function | is a member of the membrane-spanning 4A gene family. |
| Primary Expression | the central nervous system and may play roles in neurodegenerative disease pathogenesis |
| Molecular Weight | 37 kDa |
| Amino Acids | 297 aa |
| Exons | 13 |
| UniProt ID | P08581 |
| NCBI Gene ID | 931 |
| Ensembl ID | ENSG00000156738 |
| OMIM | 112210 |
| GeneCards | MS4A1 |
| Human Protein Atlas | MS4A1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MS4A1["MS4A1"]
neurodegeneration["neurodegeneration"]
MS4A1 -->|"implicated_in"| neurodegeneration
style MS4A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MS4A1 in their description or question text
No additional research found