Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MTCO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MT |
| Full Name | CO1 Gene - Mitochondrially Encoded Cytochrome C Oxidase I |
| Aliases | MTCO1 |
| Function | Cytochrome b is a key component of Complex III (ubiquinol-cytochrome c reductase), which catalyzes the transfer of electrons from ubiquinol to cytochrome c. |
| GeneCards | MT |
| Human Protein Atlas | MT |
| Catalytic center | Contains heme a and heme a3, where O2 binding and reduction occur |
| Electron transfer | Receives electrons from cytochrome c and transfers to O2 |
| Proton pumping | Contributes to proton pumping across the inner membrane |
| Evolution | Encoded by mtDNA in all animals (co-evolution with nuclear-encoded subunits) |
| Hemeness | Heme a and heme a3 are unique prosthetic groups |
| Pediatric disorders | MT-CO1 mutations cause severe infantile mitochondrial disorders |
| Encephalomyopathy | Global developmental delay, lactic acidosis, cardiomyopathy |
| Heteroplasmy | Disease manifestation depends on mutant mtDNA load |
| m.7445A>G | Can cause combined LHON and sideroblastic anemia |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MTCO1["MTCO1"]
neurodegeneration["neurodegeneration"]
MTCO1 -->|"implicated_in"| neurodegeneration
style MTCO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MTCO1 in their description or question text
No additional research found