Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MTND1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MT |
| Full Name | ND1 Gene - Mitochondrial NADH Dehydrogenase Subunit 1 |
| Aliases | MTND1 |
| Function | Cytochrome b is a key component of Complex III (ubiquinol-cytochrome c reductase), which catalyzes the transfer of electrons from ubiquinol to cytochrome c. |
| GeneCards | MT |
| Human Protein Atlas | MT |
| Complex I subunit | Forms part of the membrane arm of NADH dehydrogenase |
| Electron transfer | Transfers electrons from NADH to ubiquinone |
| Proton pumping | Contributes to proton gradient generation |
| Evolutionary origin | Retained from bacterial ancestor of mitochondria |
| Conservation | Highly conserved across eukaryotes |
| Primary mutations | m.3460G>A (ND1) is a common cause of LHON[@dimauro2003] |
| Penetrance | ~40-50% of males and 10-15% of females with mutation develop optic neuropathy |
| Age of onset | Typically 15-35 years |
| Selective vulnerability | Retinal ganglion cells are particularly susceptible |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MTND1["MTND1"]
neurodegeneration["neurodegeneration"]
MTND1 -->|"implicated_in"| neurodegeneration
style MTND1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MTND1 in their description or question text
No additional research found