gene

MYO5B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYO5B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive overview of MYO5B (myosin Vb), a motor protein involved in intracellular transport, vesicle trafficking, and synaptic function, with implications for neurodegenerative diseases and microvillus inclusion disease.

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🧬 Gene Info

Gene Symbol	MYO5B
Full Name	Myosin Vb
Chromosome	18q21.1
Function	is a cytoskeletal motor that transports cargo along actin filaments, using ATP hydrolysis to generate mechanical force.
Amino Acids	843 aa
Exons	40
UniProt ID	Q9ULL5
NCBI Gene ID	4645
Ensembl ID	ENSG00000170111
OMIM	614315
GeneCards	MYO5B
Human Protein Atlas	MYO5B
Motor domain (N-terminal)	Contains the ATPase and actin-binding regions that generate force
Lever arm	Long alpha-helix that amplifies small conformational changes
Cargo-binding domain (C-terminal)	Binds to various cargo adaptors
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MYO5B — AlphaFold Q9ULL5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MYO5B — Myosin Vb

gene · 1296 words

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Pathway Diagram

graph TD
    MYO5B["MYO5B"]
    neurodegeneration["neurodegeneration"]
    MYO5B -->|"implicated_in"| neurodegeneration
    style MYO5B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity