| Symbol | LOC117134605 |
| Name | TMPRSS2 repressive element NBS1 |
| Type | biological-region |
| Source | mygene |
This locus represents a segment of the 5' regulatory region of the TMPRSS2 (transmembrane serine protease 2) gene, which functions as an entry gene for human coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). The extended promoter is responsive to androgen receptor (AR), and it drives expression of a TMPRSS2-ERG or TMPRSS2-ETV1 oncogenic fusion gene in androgen-dependent prostate cancers. This subregion, which is located 2.2 kb upstream of the gene, includes a binding site f
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