Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NCX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NCX1 |
| Full Name | Sodium Calcium Exchanger 1 |
| Aliases | NCX1 (SLC8A1) |
| Chromosome | 2p23.3 |
| Function | is a large transmembrane protein with 11 transmembrane segments organized into two functional domains |
| Primary Expression | Heart, Brain (neurons, astrocytes), Kidney, Smooth muscle |
| Molecular Weight | ~110 kDa |
| Amino Acids | 938 aa |
| UniProt ID | P32418 |
| NCBI Gene ID | 6576 |
| Ensembl ID | ENSG00000155380 |
| OMIM | 604527 |
| GeneCards | NCX1 |
| Human Protein Atlas | NCX1 |
| Protein Length | 938 amino acids |
| Interactions | TMEM16F |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NCX1["NCX1 Sodium-Calcium Exchanger"]
Ca_influx["Calcium Influx"]
Na_gradient["Sodium Gradient"]
ATP_pump["Na+/K+ ATPase"]
Ca_overload["Calcium Overload"]
Mitochondria["Mitochondrial Dysfunction"]
ROS["Reactive Oxygen Species"]
Calpains["Calpain Activation"]
Apoptosis["Neuronal Apoptosis"]
TMEM16F["TMEM16F Channel"]
Membrane_damage["Membrane Damage"]
Excitotoxicity["Excitotoxicity"]
Neurodegeneration["Neurodegeneration"]
Energy_depletion["ATP Depletion"]
Ca_influx -->|"drives"| NCX1
NCX1 -->|"exchanges"| Na_gradient
ATP_pump -->|"maintains"| Na_gradient
NCX1 -->|"reverse mode"| Ca_overload
Ca_overload -->|"triggers"| Mitochondria
Mitochondria -->|"produces"| ROS
Mitochondria -->|"causes"| Energy_depletion
Energy_depletion -->|"impairs"| ATP_pump
Ca_overload -->|"activates"| Calpains
Calpains -->|"induces"| Apoptosis
ROS -->|"promotes"| Apoptosis
TMEM16F -->|"interacts with"| NCX1
TMEM16F -->|"causes"| Membrane_damage
Excitotoxicity -->|"increases"| Ca_influx
Apoptosis -->|"leads to"| Neurodegeneration
style NCX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
style ATP_pump fill:#1a3a2a,stroke:#81c784,stroke-width:2px
style Ca_overload fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style Mitochondria fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style ROS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style Apoptosis fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style TMEM16F fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
style Neurodegeneration fill:#3a2a1a,stroke:#ffa726,stroke-width:3px
style Excitotoxicity fill:#3a1a1a,stroke:#ef5350,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TMEM16F | interacts_with | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||