gene

NCX2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NCX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

NCX2 (SLC8A2) Gene

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🧬 Gene Info

Gene Symbol	NCX2
Full Name	Sodium Calcium Exchanger 2
Aliases	NCX2 (SLC8A2)
Chromosome	15q21.3
Function	NCX2 (SLC8A2) encodes the sodium-calcium exchanger 2, a neuron-specific isoform of the NCX family that is predominantly expressed in the central and peripheral nervous systems
Primary Expression	Brain (neurons), Retina, Inner ear
Subcellular Localization	patterns that are optimized for neuronal function. The exchanger plays essential roles in maintaining calcium balance at
Molecular Weight	~105 kDa
Amino Acids	921 aa
UniProt ID	P55685
NCBI Gene ID	6577
Ensembl ID	ENSG00000126860
OMIM	607857
GeneCards	NCX2
Human Protein Atlas	NCX2
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCX2 — AlphaFold P55685 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NCX2 (SLC8A2) Gene

gene · 1225 words

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Pathway Diagram

graph TD
    NCX2["NCX2"]
    neurodegeneration["neurodegeneration"]
    NCX2 -->|"implicated_in"| neurodegeneration
    style NCX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NCX2 in their description or question text

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