Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFAF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Page for NDUFAF6 Gene - Mitochondrial Complex I Assembly Factor in neurodegeneration
| Gene Symbol | NDUFAF6 |
| Full Name | NADH Dehydrogenase Complex I Assembly Factor 6 |
| Aliases | Page for NDUFAF6 Gene |
| Chromosome | 8q24.3 |
| Function | is a critical mitochondrial protein required for the assembly of the NADH:ubiquinone oxidoreductase (Complex I) of the electron transport chain. |
| Primary Expression | dopaminergic neurons of the substantia nigra [10](https://pubmed |
| Molecular Weight | 37.8 kDa |
| UniProt ID | Q8N5Z0 |
| NCBI Gene ID | 374291 |
| Ensembl ID | ENSG00000164434 |
| OMIM | 612361 |
| GeneCards | NDUFAF6 |
| Human Protein Atlas | NDUFAF6 |
| Alternative Symbols | C8orf38, MC1, CIAO3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NDUFAF6["NDUFAF6"]
neurodegeneration["neurodegeneration"]
NDUFAF6 -->|"implicated_in"| neurodegeneration
style NDUFAF6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity