protein

NEUREXIN1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NEUREXIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	NEUREXIN1
Function	- Neurotransmitter release: Regulates vesicle docking, priming, and fusion
Subcellular Localization	</th><td>Presynaptic membrane, synaptic cleft</td></tr>
Molecular Weight	200 kDa
GeneCards	NEUREXIN1
Human Protein Atlas	NEUREXIN1
Extracellular domain	Single LNS domain
Transmembrane region	Single-pass transmembrane helix
Cytoplasmic tail	Contains multiple PDZ-binding motifs for interaction with scaffolding proteins
Presynaptic differentiation	Induces formation of presynaptic specializations, including active zones and vesicle pools [@graf2004]
Synaptic specificity	Mediates recognition between pre- and postsynaptic partners
Active zone organization	Recruits scaffolding proteins and synaptic vesicles to presynaptic terminals
Synaptic maintenance	Sustains synaptic integrity throughout development and adulthood
Neurotransmitter release	Regulates vesicle docking, priming, and fusion
Receptor function	Modulates NMDA and AMPA receptor trafficking and function
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Neurexin-1 Protein (NRXN1)

protein · 1106 words

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Pathway Diagram

graph TD
    NEUREXIN1["NEUREXIN1"]
    neurodegeneration["neurodegeneration"]
    NEUREXIN1 -->|"implicated_in"| neurodegeneration
    style NEUREXIN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Related Research

Hypotheses and analyses mentioning NEUREXIN1 in their description or question text

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