Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NF-κB_signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| cPLA2_MAVS_interaction | activates | unknown | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target | 0.619 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692] | Khan JZ, Zainab SR, Alattar A | Neurochem Res | 2025 | 0 |
| Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025] | Unknown | Journal of ethnopharmacology | 2024 | 0 |
| Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915] | Sun W, Wang Q, Zhang R, Zhang N | Food & function | 2023 | 0 |
| NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264] | Ibrahim Weam W; Skalicka-Woźniak K | International immunopharmacolo | 2023 | 0 |
| Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061] | Choi I, Zhang Y, Seegobin SP | Nat Commun | 2020 | 0 |
| Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362] | Mondal A, Bose D, Saha P | J Neuroinflammation | 2020 | 0 |
| RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890] | ["Muhammad T", "Ikram M", "Ullah R", "Re | Nutrients | 2019 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NF-κB_signaling in their description or question text
No additional research found