gene

NFAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

NFAT3 (Nuclear Factor of Activated T cells 3, also known as NFATc4) is a calcium-dependent transcription factor highly expressed in the brain where it regulates synaptic plasticity, neuronal survival, circadian rhythm, and neuroinflammation. Dysregulated NFAT3 signaling contributes to Alzheimer's disease, Huntington's disease, and stroke pathophysiology.

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🧬 Gene Info

Gene Symbol	NFAT3
Full Name	Nuclear Factor of Activated T Cells 3
Aliases	Nuclear Factor of Activated T cells 3, also known as NFATc4
Chromosome	14q11.2
Protein Family	NFAT transcription factors (NFAT1-5)
Protein Type	Transcription Factor
Function	is a member of the NFAT family of calcium-dependent transcription factors.
Primary Expression	the brain, particularly in the cortex, hippocampus, and hypothalamus, where it controls genes involved in synaptic plasticity, neuronal survival, circ
Molecular Weight	79 kDa
UniProt ID	Q12986 (NFAT3)
NCBI Gene ID	8012
Ensembl ID	ENSG00000100968
OMIM	602700
GeneCards	NFAT3
Human Protein Atlas	NFAT3
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFAT3 — AlphaFold Q12986 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NFAT3 Gene

gene · 2529 words

→

NFAT3 Protein

protein · 1022 words

→

Pathway Diagram

graph TD
    NFAT3["NFAT3 (NFATc4)
Transcription Factor"]
    
    subgraph Activation["Calcium Signaling"]
        Ca["Ca2+ Influx"]
        Calcineurin["Calcineurin
(Phosphatase)"]
        CaM["Calmodulin"]
    end
    
    subgraph Kinases["Inhibitory Kinases"]
        GSK3["GSK3beta"]
        CK1["Casein Kinase 1"]
        DYRK["DYRK1A"]
    end
    
    subgraph Targets["Transcriptional Targets"]
        BDNF["BDNF"]
        cFos["c-Fos"]
        IL2["IL-2"]
        Cytokines["Inflammatory
Cytokines"]
    end
    
    subgraph Functions["Neural Functions"]
        SynapticPlasticity["Synaptic Plasticity"]
        NeuronSurvival["Neuronal Survival"]
        Circadian["Circadian Rhythm"]
        Neuroinflammation["Neuroinflammation"]
    end
    
    subgraph Disease["Disease Links"]
        AD["Alzheimer's Disease"]
        HD["Huntington's Disease"]
        Stroke["Stroke"]
    end
    
    Ca -->|"activates"| CaM
    CaM -->|"activates"| Calcineurin
    Calcineurin -->|"dephosphorylates"| NFAT3
    NFAT3 -->|"nuclear translocation"| Targets
    
    GSK3 -->|"phosphorylates
(nuclear export)"| NFAT3
    CK1 -->|"primes for
phosphorylation"| NFAT3
    DYRK -->|"phosphorylates"| NFAT3
    
    NFAT3 -->|"induces"| BDNF
    NFAT3 -->|"activates"| cFos
    NFAT3 -->|"regulates"| IL2
    NFAT3 -->|"induces"| Cytokines
    
    BDNF -->|"promotes"| SynapticPlasticity
    NFAT3 -->|"regulates"| NeuronSurvival
    NFAT3 -->|"modulates"| Circadian
    Cytokines -->|"drives"| Neuroinflammation
    
    NFAT3 -.->|"dysregulation"| AD
    NFAT3 -.->|"dysregulation"| HD
    NFAT3 -.->|"ischemic response"| Stroke
    
    classDef mainProtein fill:#ff6b6b,stroke:#c92a2a,stroke-width:3px,color:#e0e0e0,font-size:14px
    classDef signaling fill:#4ecdc4,stroke:#0d9488,stroke-width:2px,color:#e0e0e0
    classDef kinase fill:#ffe66d,stroke:#f39c12,stroke-width:2px,color:#e0e0e0
    classDef target fill:#a8e6cf,stroke:#38ada9,stroke-width:2px,color:#e0e0e0
    classDef function fill:#95e1d3,stroke:#38ada9,stroke-width:2px,color:#e0e0e0
    classDef disease fill:#ff9999,stroke:#d9534f,stroke-width:2px,color:#e0e0e0
    
    class NFAT3 mainProtein
    class Ca,Calcineurin,CaM signaling
    class GSK3,CK1,DYRK kinase
    class BDNF,cFos,IL2,Cytokines target
    class SynapticPlasticity,NeuronSurvival,Circadian,Neuroinflammation function
    class AD,HD,Stroke disease

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NFAT3 in their description or question text

No additional research found