Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFAT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NFAT4 is a calcium-dependent transcription factor regulating synaptic plasticity, neuroinflammation, and neuronal survival in neurodegenerative diseases.
| Gene Symbol | NFAT4 |
| Full Name | Nuclear Factor of Activated T-cells 4 |
| Chromosome | 14q11.2. |
| Protein Type | Transcription Factor |
| Function | Calcium influx through voltage-gated channels or NMDA receptors |
| Molecular Weight | ~120 kDa |
| Amino Acids | 073 aa |
| Exons | 11 |
| Pathways | NF-κB |
| UniProt ID | Q12918 |
| NCBI Gene ID | 4776 |
| Ensembl ID | ENSG00000100868 |
| OMIM | 601065 |
| GeneCards | NFAT4 |
| Human Protein Atlas | NFAT4 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NFAT4["NFAT4"]
neurodegeneration["neurodegeneration"]
NFAT4 -->|"implicated_in"| neurodegeneration
style NFAT4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||