gene

NFKBIB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKBIB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

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0Experiments

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Summary

NFKBIB encodes IκBβ, an alternative NF-κB inhibitor isoform expressed in neurons and glia. Variants and expression changes contribute to neuroinflammation in Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	NFKBIB
Full Name	NFKB Inhibitor Beta
Chromosome	5p13.1
Function	inhibitor isoform expressed in neurons and glia
Primary Expression	Neurons, astrocytes, microglia
Amino Acids	359 aa
Pathways	NFKB, NF-κB, nfkb
UniProt ID	Q9BQM9
NCBI Gene ID	4793
GeneCards	NFKBIB
Human Protein Atlas	NFKBIB
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFKBIB — AlphaFold Q9BQM9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NFKBIB Gene

gene · 593 words

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Pathway Diagram

graph TD
    NFKBIB["NFKBIB"]
    neurodegeneration["neurodegeneration"]
    NFKBIB -->|"implicated_in"| neurodegeneration
    style NFKBIB fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFKBIB in their description or question text

No additional research found