gene

NHEJ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NHEJ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

NHEJ1 gene involved in DNA repair and neurodegeneration

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🧬 Gene Info

Gene Symbol	NHEJ1
Full Name	Non-Homologous End Joining Factor 1
Chromosome	2q33.3
Function	is a gene located on chromosome 2q33.
Primary Expression	Brain (ubiquitous), Thymus, Spleen, Testis
UniProt ID	Q9GZL0
NCBI Gene ID	2004
Ensembl ID	ENSG00000168421
OMIM	607351
GeneCards	NHEJ1
Human Protein Atlas	NHEJ1
DNA double-strand break repair	Joins DNA ends that lack homologous sequences
V(D)J recombination	Essential for antigen receptor gene rearrangement in B and T cells
Telomere maintenance	Involved in alternative lengthening of telomeres
Genomic stability	Prevents chromosomal translocations and deletions
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NHEJ1 — AlphaFold Q9GZL0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NHEJ1 — Non-Homologous End Joining Factor 1

gene · 711 words

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Pathway Diagram

graph TD
    NHEJ1["NHEJ1"]
    neurodegeneration["neurodegeneration"]
    NHEJ1 -->|"implicated_in"| neurodegeneration
    style NHEJ1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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