Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NMNAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NMNAT3 is a mitochondrial NAD+ synthase that protects dopaminergic neurons in Parkinson's Disease and is crucial for axon maintenance.
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| Gene Symbol | NMNAT3 |
| Full Name | Nicotinamide Mononucleotide Adenylyltransferase 3 |
| Chromosome | 3q23 |
| Protein Type | Enzyme |
| Function | is a mitochondrial enzyme critical for NAD+ biosynthesis in mammalian cells. |
| Primary Expression | Heart, liver, skeletal muscle, brain |
| Subcellular Localization | the mitochondrial matrix where it catalyzes the conversion of nicotinamide mononucleotide (NMN) to NAD+ [@nmnat3_mito_20 |
| Molecular Weight | 31 kDa |
| Amino Acids | 30 aa |
| UniProt ID | Q9H5H4 |
| NCBI Gene ID | 107150 |
| Ensembl ID | ENSG00000163644 |
| OMIM | 608710 |
| GeneCards | NMNAT3 |
| Human Protein Atlas | NMNAT3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NMNAT3["NMNAT3"]
neurodegeneration["neurodegeneration"]
NMNAT3 -->|"implicated_in"| neurodegeneration
style NMNAT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning NMNAT3 in their description or question text
No additional research found