Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOSTRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NOSTRIN |
| Full Name | Nitric Oxide Synthase Trafficking Inducer |
| Chromosome | 2q31.1 |
| Protein Family | F-Box only protein |
| Function | nNOS Trafficking: NOSTRIN binds to nNOS and facilitates its translocation to specific cellular compartments, particularly membrane fractions and dendritic processes in neurons |
| Primary Expression | Brain, endothelium, heart |
| Subcellular Localization | and activity of neuronal nitric oxide synthase (nNOS), NOSTRIN influences nitric oxide production, which is essential fo |
| Molecular Weight | 60 kDa |
| Amino Acids | 506 aa |
| UniProt ID | Q9NRC8 |
| NCBI Gene ID | 54112 |
| Ensembl ID | ENSG00000163050 |
| OMIM | 609046 |
| GeneCards | NOSTRIN |
| Human Protein Atlas | NOSTRIN |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NOSTRIN["NOSTRIN"]
neurodegeneration["neurodegeneration"]
NOSTRIN -->|"implicated_in"| neurodegeneration
style NOSTRIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NOSTRIN in their description or question text
No additional research found