gene

NOTCH4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for NOTCH4 Gene - Notch Receptor 4

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🧬 Gene Info

Gene Symbol	NOTCH4
Aliases	Page for NOTCH4 Gene
Chromosome	6q23.3
Protein Type	Receptor
Function	NOTCH4 is a member of the Notch family of transmembrane receptors that mediate cell-cell communication through conserved ligand-receptor interactions.
Primary Expression	endothelial cells and plays important roles in vascular development and blood-brain barrier formation
Pathways	NOTCH, nOTCH, Notch
Ensembl ID	ENSG00000204301
GeneCards	NOTCH4
Human Protein Atlas	NOTCH4
NOTCH3	Disease-causing gene in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
ADAM10/ADAM17	Proteases mediating NOT
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NOTCH4 Gene - Notch Receptor 4

gene · 592 words

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Pathway Diagram

graph TD
    NOTCH4["NOTCH4"]
    neurodegeneration["neurodegeneration"]
    NOTCH4 -->|"implicated_in"| neurodegeneration
    style NOTCH4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NOTCH4 in their description or question text

No additional research found