Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NPY5R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: NPY5R - Neuropeptide Y receptor implicated in energy homeostasis, neuroprotection, and metabolic disorders
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| Gene Symbol | NPY5R |
| Full Name | Neuropeptide Y Receptor Y5 |
| Aliases | Gene profile: NPY5R |
| Chromosome | 4q31.21 |
| Protein Type | Receptor |
| Function | encodes a G protein-coupled receptor (GPCR) that binds neuropeptide Y (NPY), a highly conserved 36-amino acid peptide neurotransmitter widely distributed throughout the central and peripheral nervo... |
| Primary Expression | Brain, hypothalamus, cortex, hippocampus |
| Amino Acids | 36 aa |
| UniProt ID | Q99731 |
| NCBI Gene ID | 4883 |
| GeneCards | NPY5R |
| Human Protein Atlas | NPY5R |
| Hypothalamus | Particularly dense expression in the paraventricular nucleus (PVN) and arcuate nucleus, where NPY5R participates in feeding and energy balance regulation. |
| Thalamus | Moderate expression in thalamic nuclei involved in sensory and autonomic processing. |
| Cortex | Layer-specific expression in the cerebral cortex, particularly in pyramidal neurons. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NPY5R["NPY5R"]
neurodegeneration["neurodegeneration"]
NPY5R -->|"implicated_in"| neurodegeneration
style NPY5R fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NPY5R in their description or question text
No additional research found