gene

NSD1

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This page aggregates everything SciDEX knows about NSD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for NSD1 (Nuclear Receptor Binding SET Domain Protein 1)

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🧬 Gene Info

Gene Symbol	NSD1
Full Name	Nuclear Receptor Binding SET Domain Protein 1
Chromosome	5q35.3
Protein Type	Transferase
Function	encodes a histone lysine methyltransferase of the nuclear receptor SET domain (NSD) family that catalyzes mono- and dimethylation of histone H3 at lysine 36 (H3K36me1/2).
Amino Acids	2696 aa
UniProt ID	[Q96L73](https://www.uniprot.org/uniprot/Q96L73)
Ensembl ID	ENSG00000165671
GeneCards	NSD1
Human Protein Atlas	NSD1
SET domain	Catalytic methyltransferase domain responsible for H3K36 methylation
PWWP domain	Reads existing H3K36me marks, enabling spreading of the modification along gene bodies
PHD fingers (5x)	Recognize various histone modifications for chromatin targeting
Alternative splicing regulation	H3K36me2/3 marks recruit splicing factors to pre-mRNAs during co-transcriptional processing; NSD1 loss causes widespread splicing dysregulation in neurons
Histone crosstalk	H3K36me2 antagonizes PRC2-mediated H3K27me3 deposition, maintaining the boundary between active and repressed chromatin domains
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NSD1 (Nuclear Receptor Binding SET Domain Protein 1)

gene · 1180 words

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Pathway Diagram

graph TD
    NSD1["NSD1"]
    neurodegeneration["neurodegeneration"]
    NSD1 -->|"implicated_in"| neurodegeneration
    style NSD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning NSD1 in their description or question text

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