Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NTHL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NTHL1 (Nth-like DNA Glycosylase 1) is a DNA repair enzyme involved in base excision repair, critical for maintaining genomic integrity in the brain and linked to neurodegeneration
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| Gene Symbol | NTHL1 |
| Full Name | Nth-like DNA Glycosylase 1 |
| Chromosome | 16p13.3 |
| Protein Family | Endonuclease III family |
| Function | is a DNA glycosylase that plays a critical role in the base excision repair (BER) pathway. |
| Molecular Weight | 34 kDa |
| Exons | 6 |
| UniProt ID | Q9UBC2 |
| NCBI Gene ID | 4914 |
| Ensembl ID | ENSG00000165030 |
| OMIM | 616678 |
| GeneCards | NTHL1 |
| Human Protein Atlas | NTHL1 |
| Helix-hairpin-helix (HhH) motif | Core catalytic domain for DNA binding |
| Iron-sulfur cluster (4Fe-4S) | Required for structural stability and catalytic activity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NTHL1["NTHL1"]
neurodegeneration["neurodegeneration"]
NTHL1 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NTHL1 in their description or question text
No additional research found