gene

NTSR2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NTSR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

NTSR2 (Neurotensin Receptor 2) is a G protein-coupled receptor for neurotensin, involved in neuroprotection, dopamine signaling, and modulation of neuroinflammation. Implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🧬 Gene Info

Gene Symbol	NTSR2
Aliases	Neurotensin Receptor 2
Chromosome	9p21.3
Protein Type	Receptor
Function	is a member of the G protein-coupled receptor superfamily that binds neurotensin, a 13-amino acid neuropeptide involved in pain modulation, dopamine signaling, and neuroprotection.
Primary Expression	distinct brain regions and cell types, leading to unique physiological functions and therapeutic potential in neurodegenerative diseases [@barra2021]
Amino Acids	13 aa
Exons	5
GeneCards	NTSR2
Human Protein Atlas	NTSR2
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NTSR2 Gene

gene · 2654 words

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Pathway Diagram

graph TD
    NTSR2["NTSR2"]
    neurodegeneration["neurodegeneration"]
    NTSR2 -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    NTSR2 -->|"implicated in"| Alzheimer_S_Disease
    Neurodegenerative_Conditions{"Neurodegenerative Conditions"}
    NTSR2 -->|"implicated in"| Neurodegenerative_Conditions
    Parkinson_S_Disease{"Parkinson'S Disease"}
    NTSR2 -->|"implicated in"| Parkinson_S_Disease
    Inflammation(["Inflammation"])
    NTSR2 -->|"regulates"| Inflammation
    Neuroinflammation(["Neuroinflammation"])
    NTSR2 -->|"regulates"| Neuroinflammation
    Neuroprotection(["Neuroprotection"])
    NTSR2 -->|"promotes"| Neuroprotection
    DOPAMINE["DOPAMINE"]
    NTSR2 ---|"interacts"| DOPAMINE
    style NTSR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neurodegenerative_Conditions fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neuroinflammation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Neuroprotection fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Inflammation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NTSR2 in their description or question text

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