Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NUDT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | NUDT1 |
| Full Name | NUDIX Hydrolase 1 (MTH1) |
| Chromosome | 7p22.3 |
| Protein Type | Enzyme |
| Function | The NUDT1 gene encodes a 156-amino acid enzyme that belongs to the NUDIX hydrolase family. |
| Primary Expression | cancers - Required for survival of cancer cells - Essential for removing oxidized nucleotides in proliferating cells - Cancer-specific vulnerability ( |
| Amino Acids | 156 aa |
| UniProt ID | P23939 |
| NCBI Gene ID | 4520 |
| Ensembl ID | ENSG00000240809 |
| OMIM | 600345 |
| GeneCards | NUDT1 |
| Human Protein Atlas | NUDT1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NUDT1["NUDT1"]
neurodegeneration["neurodegeneration"]
NUDT1 -->|"implicated_in"| neurodegeneration
style NUDT1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NUDT1 in their description or question text
No additional research found