gene

NUP153

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUP153: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections
0Hypotheses
0Analyses
4Outgoing
1Incoming

Summary

Page for NUP153 — Nucleoporin 153

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🧬 Gene Info
Gene SymbolNUP153
Full NameNucleoporin 153
Chromosome6p22.3
Functionencodes a 1,475-amino acid protein with a molecular weight of approximately 153 kDa.
Primary Expressionpost-mitotic neurons, where NPCs are extraordinarily long-lived
Molecular Weight153 kDa
Amino Acids475 aa
UniProt IDP49790
NCBI Gene ID9972
Ensembl IDENSG00000124789
OMIM603948
GeneCardsNUP153
Human Protein AtlasNUP153
Associated DiseasesAlzheimer's Disease, Huntington's Disease
KG Connections5 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NUP153 — AlphaFold P49790 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

NUP153 — Nucleoporin 153

gene · 1271 words

C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chain

mechanism · 3056 words

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

mechanism · 2930 words

RAN Gene

gene · 2633 words

nucleocytoplasmic-transport-4r-tauopathies

mechanism · 2372 words

SYNE2 Gene

gene · 1999 words

Pathway Diagram

flowchart TD
    N0["NUP153"]
    N1["INPP5F"]
    N1 -->|"regulates"| N0
    N2["STAU2"]
    N0 -->|"regulates"| N2
    N3["Wnt signaling"]
    N0 -->|"participates in"| N3
    N4["autophagy pathway"]
    N0 -->|"participates in"| N4
    N5["RNA"]
    N0 -->|"regulates"| N5
    N6["neurodegeneration"]
    N0 -->|"implicated in"| N6

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 gene
    class N3 pathway
    class N4 pathway
    class N5 gene

Outgoing (4)

TargetRelationTypeStr
STAU2regulatesgene0.60
Wnt signalingparticipates_inpathway0.60
autophagy pathwayparticipates_inpathway0.60
RNAregulatesgene0.60

Incoming (1)

SourceRelationTypeStr
INPP5Fregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found