| Gene Symbol | TPR |
| Full Name | Translocated Promoter Region |
| Chromosome | 1 |
| Function | The Translocated Promoter Region (TPR) is a large filamentous protein component of the nuclear pore complex (NPC) that extends into the nuclear basket. |
| Amino Acids | 163 aa |
| Ensembl ID | ENSG00000158477 |
| GeneCards | TPR |
| Human Protein Atlas | TPR |
| Nuclear basket formation | TPR forms the core structure of the nuclear basket, regulating nuclear pore permeability |
| mRNA export | TPR facilitates the export of mature mRNAs through interactions with the mRNA export receptor NXF1/TAP[@cheng2021] |
| Nuclear export of proteins | TPR regulates the export of ribosomal proteins and other large cargo |
| Chromatin organization | TPR anchors chromatin to the nuclear envelope and participates in gene regulation |
| DNA damage response | TPR recruits DNA repair proteins to nuclear pores following damage |
| Brain | High expression in neurons throughout the cortex, hippocampus, and basal ganglia |
| Neuronal localization | Nuclear envelope, with extension into the nucleoplasm |
| Associated Diseases | neurodegeneration |
| Interactions | CANCER, DDIT3, HSP90, INFLAMMATION, NEURODEGENERATION, PPP5C |
| KG Connections | 65 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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