gene

STAU2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAU2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

Page for STAU2 Gene

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🧬 Gene Info

Gene Symbol	STAU2
Full Name	Staufen2
Chromosome	8q13.3
Function	This transport is essential for local protein synthesis at synapses.
Primary Expression	neural progenitor cells and regulates genes involved in neuronal differentiation and migration
Pathways	Mtor Signaling
UniProt ID	Q9NUR2
NCBI Gene ID	27067
Ensembl ID	ENSG00000100095
OMIM	607010
GeneCards	STAU2
Human Protein Atlas	STAU2
Approach	Status
mRNA transport modulators	Research
Stress granule inhibitors	Research
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, Frontotemporal Dementia, Spinocerebellar Ataxia
Known Drugs/Compounds	rapamycin
Interactions	STAUFEN2, MTOR, mTOR, RNA, STAU1
KG Connections	77 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAU2 — AlphaFold Q9NUR2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAU2["STAU2"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    STAU2 -->|"associated_with"| Amyotrophic_Lateral_Sclerosis
    Spinocerebellar_Ataxia_Type_2{"Spinocerebellar Ataxia Type 2"}
    STAU2 -->|"associated_with"| Spinocerebellar_Ataxia_Type_2
    mTOR("mTOR")
    STAU2 -->|"activates"| mTOR
    miR_217["miR-217"]
    miR_217 -->|"targets"| STAU2
    Stress_Granule_Formation["Stress Granule Formation"]
    STAU2 -->|"activates"| Stress_Granule_Formation
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"associated_with"| STAU2
    Ataxia{"Ataxia"}
    STAU2 -->|"associated_with"| Ataxia
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    STAU2 -->|"associated_with"| Frontotemporal_Dementia
    Als{"Als"}
    STAU2 -->|"associated_with"| Als
    STAU2 -->|"therapeutic_target"| Amyotrophic_Lateral_Sclerosis
    Dementia{"Dementia"}
    STAU2 -->|"associated_with"| Dementia
    STAU1("STAU1")
    STAU1 -->|"interacts_with"| STAU2
    MTOR["MTOR"]
    STAU2 -->|"therapeutic_target"| MTOR
    AND["AND"]
    STAU2 -->|"expressed_in"| AND
    STAU2 -->|"therapeutic_target"| C9ORF72

Outgoing (50)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Mrna Trafficking	regulates	process	0.95
Spinocerebellar Ataxia Type 2	associated_with	disease	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
MTOR	activates	protein	0.85
Mtor Signaling	involved_in	pathway	0.85
mTOR	activates	protein	0.85
Stress Granule Formation	activates	process	0.80
stress granules	induces_formation	organelle	0.80
amyotrophic lateral sclerosis	overabundant_in	disease	0.80
Ataxia	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
MTOR	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
neurodegeneration	expressed_in	disease	0.60
cerebellum	expressed_in	brain_region	0.60
AND	expressed_in	gene	0.60
DEMENTIA	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
Mtor	therapeutic_target	pathway	0.60
STAU1	associated_with	gene	0.60
Fibroblast	associated_with	cell_type	0.60
ALS	associated_with	gene	0.60
Mtor	expressed_in	pathway	0.60
Raf	regulates	protein	0.60
Tau	therapeutic_target	protein	0.60
frontotemporal dementia	associated_with	disease	0.60
Wnt signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Spinal Cord	expressed_in	brain_region	0.55
Fibroblast	expressed_in	cell_type	0.55
STAUFEN2	interacts_with	protein	0.50
DEMENTIA	expressed_in	gene	0.50
FRONTOTEMPORAL DEMENTIA	expressed_in	disease	0.50
Ataxia	expressed_in	disease	0.50
Spinocerebellar Ataxia	expressed_in	disease	0.50
FRONTOTEMPORAL	expressed_in	concept	0.50
FIBROBLASTS	expressed_in	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50
RAPAMYCIN	activates	concept	0.50
Microrna	inhibits	pathway	0.50
disease	inhibits	disease	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
MTOR SIGNALING	associated_with	concept	0.50
benchmark_ot_ad_answer_key:STAU2	data_in	dataset_row	0.00

Incoming (27)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
MIR217	targets	gene	0.90
miR-217	targets	biomarker	0.85
MIR217	downregulates	gene	0.85
Rnai	targets	mechanism	0.80
C9ORF72	associated_with	gene	0.75
STAU1	interacts_with	protein	0.65
MTOR	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
MTOR	expressed_in	gene	0.60
C9ORF72	targets	gene	0.60
NUP153	regulates	gene	0.60
STAU1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
DEMENTIA	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
RNA	inhibits	gene	0.60
AND	expressed_in	gene	0.60
RNA	regulates	gene	0.60
rapamycin	targets	drug	0.60
INPP5F	regulates	gene	0.60
mTOR	activates	entity	0.50
mTOR	associated_with	entity	0.50
mTOR	inhibits	entity	0.50
benchmark_ot_ad_answer_key:STAU2	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STAU2

Understanding Entity Pages

Summary

Wiki Pages (10)

STAU2 Gene

RNA Stability and Decay

hnrnpm

RNA Metabolism in Alzheimer's Disease

P-Body (Processing Body) Pathway in Neurodegeneration

NUP153 — Nucleoporin 153

ELAVL3 Protein

Staufen2 Protein