gene 2,633 words KG: RAN
Contents

RAN Gene

🧬 Gene Info
Gene SymbolRAN
Chromosome12q24.1
Amino Acids216 aa
Exons8
PathwaysEpigenetic, Notch, Circadian Rhythm, Tumor Microenvironment, Lipid Metabolism
GeneCardsRAN
Human Protein AtlasRAN
StateNucleotide
RAN-GTPGTP
RAN-GDPGDP
TransitionNone
ProteinRole
RCC1Chromatin-bound
RANBP1Cytoplasm
NUTF2Transport factor
Associated DiseasesAging, Als, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, Huntington
Known Drugs/Compoundsrapamycin, metformin
InteractionsC9ORF72, G3BP1, Rb, RB1, RB1CC1, SMCR8
KG Connections155 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57

Related Analyses (21)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 33 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 33 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 33 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 33 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 33 hypotheses

Knowledge Graph (12 edges)

RAN regulates MARK2
RAN regulates C9ORF72
RAN associated_with GAIN
RAN regulates DDX3X
RAN inhibits C9ORF72
RAN regulates CLOCK
RAN regulates MYC
RAN associated_with DMPK
RAN associated_with TAU
RAN associated_with C9ORF72