pathway

Wnt signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Wnt signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

1Hypotheses

0Analyses

10Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Wnt signaling
Key Genes/Proteins	GSK3, GSK3B, WNT, PI3K, TREM2, APP
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Wnt_signaling["Wnt signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Wnt_signaling["Wnt signaling"] -->|"mediates"| tau_phosphorylation["tau phosphorylation"]
    style tau_phosphorylation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Wnt_signaling["Wnt signaling"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Wnt_signaling["Wnt signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Wnt_signaling["Wnt signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Wnt_signaling["Wnt signaling"] -->|"crosstalk with"| synaptic_plasticity["synaptic plasticity"]
    style synaptic_plasticity fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Wnt_signaling["Wnt signaling"] -->|"mediates"| amyloid_aggregation["amyloid aggregation"]
    style amyloid_aggregation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    GSK3["GSK3"] -->|"participates in"| Wnt_signaling["Wnt signaling"]
    style GSK3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GSK3B["GSK3B"] -->|"participates in"| Wnt_signaling["Wnt signaling"]
    style GSK3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    WNT["WNT"] -->|"participates in"| Wnt_signaling["Wnt signaling"]
    style WNT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| Wnt_signaling["Wnt signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"participates in"| Wnt_signaling["Wnt signaling"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Wnt_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (88)

Target	Relation	Type	Str
astrocytes	active_in	cell_type	0.70
tau phosphorylation	mediates	process	0.70
neurons	active_in	cell_type	0.70
unfolded protein response	crosstalk_with	pathway	0.60
microglia	active_in	cell_type	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
amyloid aggregation	mediates	process	0.60
temporal lobe	active_in	brain_region	0.60
neural stem cells	active_in	cell_type	0.60
oligodendrocytes	active_in	cell_type	0.60

Incoming (449)

Source	Relation	Type	Str
GSK3	participates_in	gene	0.90
GSK3B	participates_in	gene	0.90
WNT	participates_in	gene	0.80
PI3K	participates_in	gene	0.80
TREM2	participates_in	gene	0.80
APP	participates_in	gene	0.80
MAPT	participates_in	gene	0.80
BACE1	participates_in	gene	0.80
MAPK1	participates_in	gene	0.80
ERK	participates_in	gene	0.80
SNCA	regulates	gene	0.75
RNA	participates_in	gene	0.70
Alzheimer's disease	involves	disease	0.70
MET	participates_in	gene	0.70
MYC	participates_in	gene	0.70
PKM2	participates_in	gene	0.70
ATG	participates_in	gene	0.70
MTOR	participates_in	gene	0.70
GAPDH	participates_in	gene	0.70
SIRT1	participates_in	gene	0.70
MAP1LC3	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
LC3	participates_in	gene	0.70
AMPK	participates_in	gene	0.70
BECN1	participates_in	gene	0.70
WIF1	participates_in	gene	0.70
AKT	participates_in	gene	0.70
MMP2	participates_in	gene	0.70
PSEN1	participates_in	gene	0.70
LRP1	participates_in	gene	0.70
CDK5	participates_in	gene	0.70
glioblastoma	involves	disease	0.70
TGF	participates_in	gene	0.70
VEGFA	participates_in	gene	0.60
C3	participates_in	gene	0.60
Parkinson's disease	involves	disease	0.60
neurodegeneration	involves	disease	0.60
HIF	participates_in	gene	0.60
HDAC3	participates_in	gene	0.60
LRRK2	participates_in	gene	0.60
FUS	participates_in	gene	0.60
MDM4	participates_in	gene	0.60
MCL1	participates_in	gene	0.60
IDH1	participates_in	gene	0.60
TERT	participates_in	gene	0.60
GLUT1	participates_in	gene	0.60
FOXO	participates_in	gene	0.60
HK2	participates_in	gene	0.60
HSPA8	participates_in	gene	0.60
RUBCN	participates_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibitory Neuron-Selective WNT Signaling Restoration	0.390	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positi [PMID:32248976]	Shen G, Gao Q, Liu F, Zhang Y, Dai M et	Biochem Biophys Res Commun	2020
WNT signalling in the normal human adult testis and in male germ cell neoplasms. [PMID:32667987]	Young JC, Kerr G, Micati D, Nielsen JE,	Hum Reprod	2020
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-cat [PMID:28811361]	Emons G, Spitzner M, Reineke S, Möller J	Mol Cancer Res	2017
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. [PMID:24605829]	Meinhardt G, Haider S, Haslinger P, Proe	Endocrinology	2014
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signa [PMID:15650056]	Tickenbrock L, Schwäble J, Wiedehage M,	Blood	2005

Wnt signaling

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Parthanatos in Neurodegeneration

Therapeutics

NRF2 Oxidative Stress Pathway

GSK-3β in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

blood-brain-barrier

Niemann-Pick Disease Type C (NPC)

MACF1 — Microtubule-actin crosslinking factor 1

Cellular Reprogramming Therapies for Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

NF-kB Signaling Pathway in Neurodegeneration

DDX3X Gene

Neurogenesis

Neurogenesis and Neurodegeneration

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

WNT4 Gene

TBX2 — T-Box Transcription Factor 2