Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NUP214: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NUP214 |
| Full Name | Nucleoporin 214 (CAN) |
| Chromosome | 9q34.13 |
| Function | encodes a 2,090-amino acid protein with a molecular weight of approximately 214 kDa. |
| Primary Expression | all tissues but is particularly critical in neurons due to their dependence on efficient mRNA export for synaptic protein synthesis |
| Molecular Weight | 214 kDa |
| Amino Acids | 090 aa |
| UniProt ID | P35658 |
| NCBI Gene ID | 8021 |
| Ensembl ID | ENSG00000126883 |
| OMIM | 114350 |
| GeneCards | NUP214 |
| Human Protein Atlas | NUP214 |
| mRNA-protein complexes | Transcripts encoding PSD-95, AMPA receptors, and NMDA receptors required for synaptic function |
| Signal transduction molecules | Activated MAPK/ERK pathway components that shuttle between nucleus and cytoplasm |
| Associated Diseases | Alzheimer's Disease, Acute Febrile Encephalopathy |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NUP214["NUP214"]
neurodegeneration["neurodegeneration"]
NUP214 -->|"implicated_in"| neurodegeneration
style NUP214 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NUP214 in their description or question text
No additional research found