protein

NUP54PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUP54PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Nucleoporin 54 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	NUP54PROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	all eukaryotic cells:
Subcellular Localization	- Nuclear envelope - Nuclear pore complexes - Cytoplasmic side of NPC ## Role i
Molecular Weight	55 kDa
GeneCards	NUP54PROTEIN
Human Protein Atlas	NUP54PROTEIN
N-terminal domain	Interaction with NUP58
Central coiled-coil domain	Structural scaffold
C-terminal FG repeats	Nucleocytoplasmic transport barrier
Molecular weight	~55 kDa
Inheritance	Autosomal recessive
Mutations	Loss-of-function variants
Features	Ataxia, cerebellar degeneration
Mechanism	Impaired nucleocytoplasmic transport
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Nucleoporin 54

protein · 638 words

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Pathway Diagram

graph TD
    NUP54PROTEIN["NUP54PROTEIN"]
    neurodegeneration["neurodegeneration"]
    NUP54PROTEIN -->|"implicated_in"| neurodegeneration
    style NUP54PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NUP54PROTEIN in their description or question text

No additional research found