Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NUP62: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NUP62 |
| Full Name | Nucleoporin 62 |
| Chromosome | 19q13.33 |
| Function | This trimeric complex forms the constriction ring of the NPC and is essential for |
| Molecular Weight | 62 kDa |
| Amino Acids | 522 aa |
| UniProt ID | P37198 |
| NCBI Gene ID | 23636 |
| Ensembl ID | ENSG00000213024 |
| OMIM | 605815 |
| GeneCards | NUP62 |
| Human Protein Atlas | NUP62 |
| Selective permeability | Creating the FG-hydrogel that discriminates cargo by size and transport receptor binding |
| NPC biogenesis | Required for de novo NPC assembly during interphase and post-mitotic NPC reconstitution |
| NPC maintenance | Turnover and replacement of damaged nucleoporins in long-lived neurons |
| Associated Diseases | Huntington's Disease, Infantile Bilateral Striatal Necrosis |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NUP62["NUP62"]
neurodegeneration["neurodegeneration"]
NUP62 -->|"implicated_in"| neurodegeneration
style NUP62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NUP62 in their description or question text
No additional research found