gene

NUS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

0Outgoing

2Incoming

0Experiments

0Debates

Summary

NUS1 (COQ8B/NgBR) is essential for coenzyme Q biosynthesis, mitochondrial function, and is linked to Parkinson's disease and primary CoQ10 deficiency.

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🧬 Gene Info

Gene Symbol	NUS1
Full Name	NUS1 Homolog, Nogo-B Receptor (Coenzyme Q Biosynthesis Factor)
Aliases	COQ8B/NgBR
Chromosome	6p22.1.
Protein Type	Enzyme
Function	encodes a critical component of the coenzyme Q (CoQ) biosynthesis pathway.
Molecular Weight	35 kDa
Amino Acids	344 aa
UniProt ID	[Q9BWM7](https://www.uniprot.org/uniprot/Q9BWM7)
Ensembl ID	ENSG00000153989
OMIM	618911
GeneCards	NUS1
Human Protein Atlas	NUS1
Electron Carrier	Transfers electrons from complex I and complex II to complex III in the electron transport chain, enabling ATP synthesis
Antioxidant	Neutralizes reactive oxygen species (ROS) and protects mitochondrial membranes from oxidative damage
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NUS1["NUS1"]
    neurodegeneration["neurodegeneration"]
    NUS1 -->|"implicated_in"| neurodegeneration
    style NUS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (2)

Source	Relation	Type	Str
genes-nus1	linked_to	wiki	1.00
genes-nus1	describes	wiki	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NUS1 in their description or question text

No additional research found