gene

NYAP1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NYAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for NYAP1 — Neuronal Tyrosine-Phosphorylated Adaptor

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🧬 Gene Info

Gene Symbol	NYAP1
Full Name	Neuronal Tyrosine-Phosphorylated Adaptor for Phosphoinositide 3-kinase
Function	NYAP1 participates in critical neuronal signaling pathways:
Primary Expression	the brain and plays important roles in neuronal migration, synaptic plasticity, and neuronal survival
Molecular Weight	42 kDa
Amino Acids	380 aa
Pathways	PI3K, PI3K Signaling
GeneCards	NYAP1
Human Protein Atlas	NYAP1
PI3K Signaling	NYAP1 links activated receptors to PI3K/Akt signaling, a critical pathway for neuronal survival.<sup>[3]</sup>
Neuronal Migration	Involved in cortical neuronal migration during development.
Synaptic Plasticity	Dysregulation of NYAP1 may contribute to synaptic dysfunction in AD.
Neuronal Survival	PI3K/Akt signaling is neuroprotective. NYAP1 variants may impair this survival pathway.
[Tau](/proteins/tau) Phosphorylation	Akt regulates tau phosphorylation; NYAP1 variants may affect this pathway.
High Expression	Cerebral cortex, hippocampus, cerebellum
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NYAP1["NYAP1"]
    neurodegeneration["neurodegeneration"]
    NYAP1 -->|"implicated_in"| neurodegeneration
    style NYAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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