Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P00519: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | P00519 |
| Aliases | ABL1 non-receptor tyrosine kinase |
| Chromosome | 9q34. |
| Protein Family | Tyrosine Kinase (non-receptor) |
| Protein Type | Receptor |
| Function | It promotes actin polymerization and stress fiber formation through interactions with various cytoskeletal proteins. |
| Primary Expression | Ubiquitous, high in brain |
| Subcellular Localization | Cytoplasm, nucleus |
| Molecular Weight | 120 kDa |
| UniProt ID | [P00519](https://www.uniprot.org/uniprot/P00519) |
| GeneCards | P00519 |
| Human Protein Atlas | P00519 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["P00519"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||