protein

P16234

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about P16234: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Calcineurin Protein (PPP3CA)

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🔬 Protein Info

Gene Symbol	P16234
Protein Type	Serine/Threonine Phosphatase
Function	is a calcium/calmodulin-dependent serine/threonine phosphatase that plays a critical role in cellular signaling, synaptic plasticity, and immune response.
Molecular Weight	64 kDa
GeneCards	P16234
Human Protein Atlas	P16234
Catalytic A subunit (PPP3CA)	A 59-64 kDa protein containing the phosphatase active site, a calmodulin-binding domain, and an auto-inhibitory domain that regulates enzyme activity
Regulatory B subunit (PPP3R1)	An 19 kDa calcium-binding protein belonging to the calmodulin superfamily that confers calcium sensitivity to the complex
T-cell activation	NFAT-regulated genes control interleukin-2 production and T-cell proliferation
Synaptic plasticity	NFAT signaling modulates long-term potentiation and memory formation
Cardiac development	NFAT coordinates cardiac morphogenesis in response to mechanical stress
Neuronal differentiation	NFAT influences neurogenesis and neuronal subtype specification
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calcineurin Protein (PPP3CA)

protein · 2442 words

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Pathway Diagram

graph TD
    P16234["P16234"]
    neurodegeneration["neurodegeneration"]
    P16234 -->|"implicated_in"| neurodegeneration
    style P16234 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning P16234 in their description or question text

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